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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Standard Interactions:
Medication InteractionStrengthHow to Take it
Nitrates20-40mg/hrCialis 10mg/hrTadalafil 20mg/hr
Alpha-blockers5mg/tabCialis 5mg/tabTadalafil 5mg/tab

C.

Cialis (tadalafil) can interact with certain foods and beverages, such as grapefruit and grapefruit juice, and its effects can amplify alcohol's effects on the kidneys (EdixITY-30). It is advisable to avoid consuming grapefruit or grapefruit juice while taking Cialis.

D.

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References

  1. Viagra (Sildenafil) - price comparisons and more information. Food and Drug Administration. Accessed March 12, 2022. https://www.accessdata.fda.gov/drug/08/08_08/i/edex/008/i/03/53517/].
  2. Cialis (Tadalafil) - generic vs. brand name. Generic andulpredis.com. https://www.trinidadannual.com/data/pricing/product/generic-cialis-tadalafil-brand-name/articles/201905_08_08_18/generic-cialis-tadalafil-brand-name/generic-cialis-tadalafil-brand-price.hra.anova.
  3. Online Prescribing Information Service. Pharmacy. https://www.pharmacy.gov.uk/publication/drug-norway/online-prescriptions-information-services/drug-norway-in-use/307430–202212.pdf. Updated April 2023.

Generic Viagra (Sildenafil) - price comparisons and more information. https://www.accessdata.fda.gov/drug/08/08_08/i/ 03/53517/ - Prescriber (25-Apr-2023). Retrieved March 12, 2022, from https://www.fda.gov.au/publication/drug-norway/prices/generic-viagra-price-cvs.hra.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Show Moreuspolar heartbeat palpitations can occur during Cialis use.inka klein can be very sleepy and not very hungry. tell your health care provider if you have increased palpitations or palpitations have been under more high-pains than normal. can be very dizzy. if you experience chest pain during Cialis, call your doctor immediately. can be very sleepy and not very hungry. tell your health care provider if you are dizzy, have nausea, and feel light headedness during sex. nausea and vomiting may occur. If any of these apply to you, contact your doctor immediately.WarningsAnd Pulmonary Hypertension angina pallidol can be very dizzy. tell your health care provider if you have had a heart attack, stroke, heart failure, heart attack, or liver disease. tell your health care provider if you are having surgery or are currently using any medications that can affect the way your body processes or absorbs medication. tell your health care provider if you are having surgery or are currently using any medications that can affect the way your body absorbs medication.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis + Erectile Dysfunction — https://www.tldc.com/product/9612130/Cialis-Erectile-Dysfunction/

As with all prescription medications, inform of all medications and supplements you are taking so that you can prevent any adverse reactions.

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Cialis is used to treat erectile dysfunction in men. It is also used to treat benign prostatic hyperplasia (BPH) in women. Cialis may also be used for the treatment of BPH in men. Cialis works by increasing blood flow to the penis. This may continue for several weeks after you stop using Cialis.

Cialis may be taken in any dose, with or without food. The recommended dose of Cialis for adults and children over 12 is 10 mg once a day. Drink a full glass of water while taking Cialis.

Ask a doctor before using Cialis if you have ever had an allergic reaction to Cialis, or any ingredient in Cialis.

The time of first taking Cialis will depend on the cause of your erectile dysfunction, your age, disease, and other conditions. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Cialis may affect the way other medicines work or may affect your health.

Do not take Cialis if you are allergic to any of its ingredients. For example, tell your doctor if you have been diagnosed with pulmonary arterial hypertension (PAH) or if you have ever had a heart attack or stroke.

Do not take Cialis if you are taking nitrate medications for chest pain or heart failure (such as isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin).

Before you start taking Cialis, talk to your doctor about the effects you may have on your erectile function. Ask your doctor about any other medicines you are taking.

If you take any of the medicines listed above, you should not take Cialis as the body adjusts to the medicine.